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A member asked:
How many single gene disorders are there?
A doctor has provided 1 answer
The notable: Bcr-abl is a single translocated change in chrinic myelogenous leukemia. The target drug (imatinib, gleevec) controls the mutation, and the disease. Gi stromal tumors, gist, has c-kit managed by the same drug, but resistance occurs. Common cancers are poly-mutated genes. Even brca-1 =2 mutation convey risk in breast and ovarian cancer, not just one gene= cancer.
Answered 6/9/2012
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