What is interstitial cystitis caused by?

Breakdown in GAG: There is a breakdown in the gag layer of the bladder. Gag stands for glucoseaminoglycan and it is a microscopic layer that is supposed to help with protection of the mucous layer of the bladder. There is a lot of research going into this area and there is a significant connection between interstitial cystitis and endometriosis. Right now we are managing the symptoms as best we can. No cure yet!

Unknown: Although IC seems to be more common in women with other ayto0immue processes, there is no known "cause" for IC. Interstital Cystitis is more of a compilation of symptoms rather that a true "condition". Therefore, treating the symptoms, e.g. urinary frequency and urgency, pain in the bladder area, painful intercourse, pelvic pain, etc., is the best approach to improving outcomes.