A member asked:

Missed dose of 100mg zoloft (sertraline) on monday. took regular dose on tuesday. what will happen if i miss wednesday's dose?

A doctor has provided 1 answer

Less Effective: Missing doses decreases the amount of the medication in your system and will lessen the effectiveness of the medication. The half-life of Zoloft (sertraline) is 26 hours. When you do not take it for a day, the medication in your system is roughly half of what your doctor feels you need.

Answered 6/20/2021

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