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Rockaway, NJ
A 29-year-old female asked:

Missed dose of 100mg zoloft (sertraline) on monday. took regular dose on tuesday. what will happen if i miss wednesday's dose?

1 doctor answer1 doctor weighed in
Dr. Marc Zimmermann
Psychiatry 23 years experience
Less Effective: Missing doses decreases the amount of the medication in your system and will lessen the effectiveness of the medication. The half-life of Zoloft (sertraline) is 26 hours. When you do not take it for a day, the medication in your system is roughly half of what your doctor feels you need.
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Last updated Jun 20, 2021

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