Can i take naproxen 250mg with tramadol 50mg as i have ran out of ibuprofen 500mg and the pain in ankle is 10/10 pain also taking prednisolone 5mg x8 time in the morning will that have any affect?

Nsaids: Naprosyn (naproxen) and Ibuprofen are both NSAIDS, so you can not take both, but you may take naprosyn (naproxen) as instructed to instead of the Ibuprofen,..BUT note, it is important for continuity of care and good pt/Dr relations to inform your treating Doctor of the medications you are taking so they can be properly documented and that allows the Doctor to know how you are and stay in tuned with your case.

Not advisable: It's generally not advisable to take NSAIDS like naproxen and ibuprofen when you are on corticosteroids such as prednisolone because of the increased risk of gastric ulceration and gastrointestinal bleeding. Consult your physician and if he or she advises that your should take both types of medication together ask him to prescribe a proton pump inhibitor to reduce risk of gastric ulceration.

For most you: Can take naproxen and tramadol together. Again for most you can even take all three(including the prednisolone) without too much issue, but you should be very careful to protect your stomach as naproxen and prednisolone could increase the chance of developing inflammation of the stomach lining and possible bleeding. Take the naproxen with food. Zantac (ranitidine) or Prilosec can help protect your stomach.

The naproxen can: substitute for the ibuprofen but the question is why do yo have so much pain? that needs to be looked at and fixed.