How will botulism cause muscle paralysis?

See answer below: Botulinum neurotoxins essentially prevent the release of acetylcholine (neurotransmitter) in the synaptic cleft, thus preventing the trigger of muscle contraction. The paralysis in the skeletal muscle lasts for about 3 months. It lasts up to 9-12 months if used in the detrusor muscle in the bladder. Strength eventually returns when new connections are created between the nerves and the muscles.