A member asked:

Will there be a zoloft (sertraline) and metoprolol tartrate interaction?

10 doctors weighed in across 2 answers

Possibly: Sertraline may potentiate the effect of metoprolol. It may cause the heart to beat at a slower rate than normal. Symptoms of this condition include dizziness, chest pain, and fainting.

Answered 11/27/2017

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Possible: Sertraline, brand name zoloft, (sertraline) can increase the level or effect of metoprolol by affecting the hepatic enzyme cyp2d6 metabolism but only above 150mg/day. You may need a lower dose of metoprolol to compensate. More important is that metoprolol, blocks Adrenalin and gets into the brain, possibly causing worse depression, fatigue and concentration problems. Don't worry unless you note a problem.

Answered 5/10/2019

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Is it ok to take toprol (metoprolol) XR and Zoloft together?

4 doctors weighed in across 2 answers