A member asked:

I take endep10 at night for weak sensitive bladder. can i take 10g 5htp in the morning? as endep10 is a low dose?? thanks

A doctor has provided 1 answer
Dr. Ralph Morgan Lewis answered

Specializes in Family Medicine

Altho your dose of …: Endep (amytriptyline) is low, both it and 5-HTP increase serotonin levels which may lead to elevated blood pressure & increased heart rate (potentially leading to shock); so it's best NOT to use this combination of drugs. Further, HTP causes drowsiness, so taking it in the AM may be problematic, as amitriptyline also causes drowsiness Have FP review problems & meds to find safer combination.

Answered 1/9/2015

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Thank

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