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A member asked:
Why do serotonin-affecting (serotonergic) drugs cause pupils to enlarge?
A doctor has provided 1 answer
Norepinephrine: Serotonin has no effect on pupil size. On the other hand, many serotonin-affecting antidepressants also inhibit the repuptake of norepinephrine (NE), causing NE levels in the extracellular space to increase. When NE levels rise, the iris muscle is stimulated to contract, thus causing pupils to appear large. Some AD meds also block acetycholine, and that can cause dilated pupils also.
Answered 5/8/2016
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