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A member asked:
If a drug has a low volume of distribution, do you give a higher dose?
A doctor has provided 1 answer
Not generally: A low volume of distribution means that the drug spreads though a relatively smaller space than if the VOD was larger, so a lower dose of the drug will lead to a relatively higher concentration within that space. So in general, you have it backwards. That said, pharmacokinetics is different for each drug and also dependent on various host conditions, so the answer can vary with specifics.
Answered 11/28/2017
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