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A 49-year-old member asked:

if a drug has a low volume of distribution, do you give a higher dose?

1 doctor answer4 doctors weighed in
Dr. Nicholas Fogelson
Specializes in Gynecology
Not generally: A low volume of distribution means that the drug spreads though a relatively smaller space than if the VOD was larger, so a lower dose of the drug will lead to a relatively higher concentration within that space. So in general, you have it backwards. That said, pharmacokinetics is different for each drug and also dependent on various host conditions, so the answer can vary with specifics.

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Last updated Nov 28, 2017

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