A 38-year-old member asked:
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what does the des in desloratdine mean?

2 doctor answers
Dr. Heidi Fowler
25 years experience Psychiatry
It is an: antihistamine. I don't know why the name starts with DES.
Answered on Jun 21, 2015
Dr. Susan Wingo
33 years experience Endocrinology
Something missing: Des- in chemical use means a molecule that is missing some atoms present in the original molecule. Loratidine is broken down in the body (metabolized) to several break-down products, or metabolites. One of these is desloratidine, which is more active against allergies than the original loratidine. It is missing a side chain with 3 Carbons, 2 Oxygens, and 4 Hydrogens.
Answered on Jul 6, 2017

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Major, for some. : Female infants of mothers who got DES in pregnancy were possiibly affected. They could have uterine malformations making it hard to carry a baby to te ... Read More
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