A member asked:

What are the tests for neuroleptic malignant syndrome?

7 doctors weighed in across 3 answers

Several!: Neuroleptic malignant syndrome is a diagnosis of exclusion, so we have to make sure there isn't another problem like an infection. Blood count may show high white blood cells, urine test may have myoglobin. If tests like blood and urine culture show no signs of infection, ct/mri of the head show no brain problems and the patient is on or has taken an antipsychotic this points us towards nms.

Answered 5/3/2013

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Dr. James Henning answered

Specializes in Anesthesiology

Clinical Tests..: Determining the presence of this syndrome is difficult to anticipate using most laboratory diagnostic aids. Individuals using certain prescribed ssri's can manifest the syndrome of excessive serotonin secretion, especially in the presence of MAO inhibitor drugs. Tests, therefore, are those clinical signs and symptoms that occur after-the-fact.

Answered 6/22/2017

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Dr. James Schlichting answered

Specializes in Medical Psychotherapy

Doctors look for an elevated creatinine phosphokinase level (muscle), myoglobin in the urine, an elevated white blood cell count, declining renal (kidney) function, and evidence of an acidotic state. Liver enzymes can be mildly elevated. Also, drug screening to look for offending agents when the patient cannot provide adequate history. Neuroimaging and LP to rule out structural/infection cause

Answered 3/15/2023

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