What are common therapies for multiple sclerosis?

History: Originally, used interferons, such as Avonex, Betaseron, Rebif; and Copaxone. But these are of very mediocre benefit. Tysabri (natalizumab) and Gilenya seem very effective, but now we have Lemtrada, the most potent of all, but very risky. Two other oral agents might be considered, Aubagio and Tecfidera. Plegridy just arrived, but in my opinion is just an updated Avonex. The TIW Copaxone form is easy to use.