If someone gets all three hepatitis b vaccines and a titer still indicates no immunity, what does this mean?

Hep B non-responders: 5-15% of people do not develop the appropriate antibodies following the 3 vaccine series for Hepatitis B. If the series is repeated and there is again no response (30-50% of people WILL respond after a second series), the person is considered a 'nonresponder'. Nonresponders should be counseled about Hep B transmission and offered HBIG if exposed.