I'm in af also cad. now taking pradaxa, may be change into plasmin (anti-coagulant drugs from china, lumbrokinase)?

Pradaxa vs lumbrokin: I would NOT recommend this - while Pradaxa is costly - it comes with the approval of the FDA along with extensive testing for efficacy and safety. From my research Lumbrokinase is derived from earthworms and is still considered investigational. I would be leery of any medications obtained from off shore (NO I do NO work for big Pharma) their safety and efficacy are unproven.