Is it safe to take seroquel (quetiapine) and trazodone together my doctor told me to take 450mg seroquel (quetiapine) xr and 100mg of trazadone at bedtime for severe insomnia?

Gotta trust your doc: Severe Sx sometimes require aggressive medication use. These doses seem high, but are not out of the ballpark and may be required for your condition. You should discuss with your doc.

Medication: Interaction. The two of these medications together have an additive effect in that they both will increase central nervous system depression and cause psychomotor impairment. In other words, they will both make you sleepy.