A 35-year-old member asked:
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what is edwards syndrome (trisomy 18)? what causes it?

2 doctor answers
Dr. Gregory Mosolf
24 years experience Pediatrics
Extra chromosome: In trisomy 18 the patient has an extra chromosome 18. This genetic disorder frequently causes heart and kidney defects. They may have a small head and jaw and usually have severe developmental delay. Here is a link http://www.Trisomy18.Org/site/pageserver?Pagename=whatist18_whatis.
Answered on Mar 31, 2016
3
3 thanks
Dr. James Ferguson
45 years experience Pediatrics
Non-disjunction: When cells divide to form an egg,the nl chromosomes (Chms) line up in pairs & one of each (23 pairs) goes to the egg .When the 18 Chms do not separate & 2 end up going to the egg, it will have 22 single Chms & a double 18 that combines with 23 single Chms brought by the sperm.Edwards syndrome represents 22 pairs & one triplet (18).The extra confuses the cells,resulting in malformations/disability.
Answered on Dec 11, 2019

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Related questions:

A 30-year-old member asked:
Dr. Gregory Mosolf
24 years experience Pediatrics
Extra chromosome: In trisomy 18 the patient has an extra chromosome 18. This genetic disorder frequently causes heart and kidney defects. They may have a small head an ... Read More
13
13 thanks
A 30-year-old member asked:
Dr. James Ferguson
45 years experience Pediatrics
Keep them comfortabl: These patients are supported with comfort measures as much as possible. Fluids, nutrition, oxygen, etc.As a universally fatal disorder, management fo ... Read More
A 45-year-old member asked:
Dr. Craig Uhl
Dr. Craig Uhl answered
26 years experience Pediatrics
Trisomy18.org: There is a foundation set up for this syndrome - go to http://www.Trisomy18.Org.
A 42-year-old member asked:
Dr. Ankush Bansal
16 years experience Internal Medicine
Maybe: This is complicated. First, in most cases, there is an extra chromosome in all cells so the sperm and eggs will be genetically defective anyways & so ... Read More

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