The er doc gave me tylenol (acetaminophen) 3 for my headaches is it safe to take with fioricet 50 325 40 also i overdosed 2 months ago on tylenol (acetaminophen)

No: Fioricet (acetaminophen butalbital and caffeine) has acetaminophen as a major component. Given your prior history, taking fioricet (acetaminophen butalbital and caffeine) with Tylenol would not be recommended. Always read labels carefully. Many multisymptom cold medications have acetaminophen as a component. So never combine medications unless you check with your doctor or pharmacists.