Sooner is better!: It varies from one STD to the next and with severity of symptoms. If only discharge, without pain, it's probably safe to wait til Monday. But even here there is risk of serious complications in the next 1-2 days. For sure don't wait if you are in pain or fever, or have open sores that suggest herpes, for which effective treatment has to start early. If necessary, find an urgent care clinic.
Answered 11/29/2014
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