What is the best meds for lack of energy and depression for my mom. she also has high blood pressure. she's 54 doesn't talk much outside the house. ?

Sounds awful: Your mom needs to see a good psychiatrist to treat her depression and also needs to rule out organic abnormalities, such as thyroid.

See a doctor: There is no medicine for lack of energy;it is probably a symptom of her depression which can be treated with therapy and/or medication.If she has high blood pressure,she must see a physician to get it under control.

She needs a doctor: Go with her to her doctor and get a referral for a Phd psychologist and a psychiatrist. This way she can get the therapy she needs and get on the best medications for her system. Her quality of life depends on this and you are a wonderful daughter for helping her.