Mid mixtures: Prednisone can awaken and excite and increase appetite and elevate glucose. Nyquil is drying and slightly sedating. Mucinex (guaifenesin) dm is drying and slightly sedating. Taken together the result likely will be slight sedation and decongestion. Why not set aside Mucinex (guaifenesin) when you take nyquil...?
Answered 1/21/2018
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