Is it safe to take benedryl and doxepin the same day?

There is caution: The combination may lead to central nervous system depression, with fatigue and dryness

Drug interaction: There is no absolute contraindication to use both doxepin and benadryl, (diphenhydramine) but concomittent use may augement the side effecst of both medications like sleepiness, dry mouth, and urianary retention in elderly male and may affect the eye pressure/glaucoma