How is sickle cell related to protein?

Types of hemoglobin: hemoglobin, which carries oxygen, can come in different forms, often associated with different inherited conditions. in sickle cell anemia, most commonly found in areas where there is a high prevalence of malaria, there is an alteration in the amino acid sequence which makes up the protein, causing sickling of the cells.

Molecular disease: Hi. Sickle cell anemia (SCA) was the FIRST described molecular basis of disease - very historic. The mutated hemoglobin gene makes a mutant hemoglobin protein called hemoglobin S (HbS). In low oxygen and/or acidic conditions, HbS is less soluble and precipitates in the red cell, producing the characteristic sickle shape of the red cell. Homozygous S/S get sick; heterozygous A/S resist malaria.