What is the difference between large and small artery?

The diamter of the: Artery. Which means the diameter is bigger.

Same: All arteries have the same basic anatomy consisting of several layers and a smooth inner lining that allows blood to flow without turbulence. One of the layers has a muscular lining which allows the artery to expand and shrink affecting flow. In larger arteries, we can bypass or clear them using new tools. Unfortunately, smaller arteries are not amenable to these things so they are hard to fix.