A member asked:

I took my last 10mg buspar (buspirone) 24 hours ago im being switched to zoloft 50mg with wellbutrin xl 150 is it safe to start zoloft now? or wait a day?

3 doctors weighed in across 2 answers
Dr. Lynne Weixel answered

Specializes in Clinical Psychology

Safe?: I'd seek a clarification consult w/ the provider about this entire plan. There are serious potential interaction risks w/ Zoloft and Wellbutrin (bupropion) xl. The doctor needs to watch you closely. You need to know what to report. I'd also urge you to consider adding CBT therapy - research consistently finds best results when that is a strong component (no side effects at all! no BP danger!). Glad you care.

Answered 10/2/2014

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YES: Should not be a problem beginning the Zoloft but I imagine your doctor let you know the regimen to change over. Buspar (buspirone) and Zoloft can be taken together typically as they affect serotonin in different ways.

Answered 10/2/2014

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Zoloft 50mg and Buspar (buspirone) 40mg a day ? Is safe?

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