Has anyone had a fine needle biopsy of a nodule?

Yes: It is a relatively painless technique for diagnosing a nodule. Depending upon the location of the nodule, it is often combined with a radiologic method to confirm correct needle placement, ie, ultrasound, ct. The main drawback is that it only yields cells for evaluation; core needle biopsy will obtain tissue but some nodules are too vascular to permit a core biopsy, ie, thyroid nodules.