A member asked:

I have a rash on my legs from using lotion i am apparently allergic to. i had one cocktail with dinner about 2 hours ago. how soon can i take benadryl (diphenhydramine)?

6 doctors weighed in across 3 answers
Dr. Roy Arnold answered

Specializes in Internal Medicine

Now's OK: As long as you aren't going to drive or do anything dangerous. Thanks for trusting HealthTap!

Answered 9/24/2014

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Dr. Saptarshi Bandyopadhyay answered

Specializes in Hospital-based practice

Depends on ur health: Metabolism of alcohol depends on many things, so it is hard to know 4 sure how much alcohol is still in your system. How many oz. did u drink? Older, obese people, those with liver problems, & certain ethnic groups metabolize more slowly. If u ate food with ur cocktail, it will slow absorption. Generally, ~10g alcohol metabolized /hr & the BAL goes dn by 0.01% per hr, so I'd wait ~4 hrs for 4 oz.

Answered 12/19/2014

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Dr. John Chiu answered

Drowsiness: Benadryl (diphenhydramine) will add to the drowsiness effect of alcohol but a 25 mg dose will not likely cause problem. However if you have a contact allergy to one of the ingredients in the lotion, topical hydrocortisone cream will likely do a better job.

Answered 9/25/2014

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