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A member asked:
Do people get used to pain and capsaiscin by producing less substance p, or by making more opioids?
A doctor has provided 1 answer
Capsaicin: not only affects substance P; other peptides such as CGRP and somatostatin are also decreased. Depletion of these neurotransmitters reduces the transmission of nociceptive information to the CNS. Capsaicin acts at a specific receptor site - the vanilloid receptor (VR1) present on both C-fibers and A-delta fibers. Nothing to do with opioids.
Answered 9/27/2014
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