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A member asked:
Can a delay in colonic cancer surgery of 2 months upstage the tumor from duke b to c ? thanks
A doctor has provided 1 answer
Yes: Colon cancer appears in a field secondary to viral transformation. The mucosal cells first mutate even though appearing normal. They then invade the submucosa and extend into the muscularis (Dukes B).to the serosa. The next step is nodal involvement (Dukes C) secondary to breakdown of e-cadherin to small e-cadherin which causes the cells to spread, in wks.
Answered 9/18/2014
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