A member asked:

Is anyone aware of any results using doxycycline 100 mg. bid for 3 months for pulmonary fibrosis? doxycycline affects matrix metaloproteinases in ipf

A doctor has provided 1 answer

IPF: A key feature of IPF is the excessive deposition of extracellular matrix and basement membrane disruption that may be at least in part due to an imbalance between secreted matrix metalloproteinases (MMPs) and their inhibitors.Doxycyline, an MMP inhibitor, was observe to decrease fibrosis, inhibiting MMPs. 2 small studies done in India have favorable outcomes although not statistically significant

Answered 9/11/2014

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