Prostaglandins (PGs): NSAIDs inhibit renal localized PGs that enhance the dilation of the renal afferent arteriole. That means that that normally, PGs keep the blood flowing nicely to the kidney. NSAIDs inhibit that effect, thus allowing less blood into the kidney resulting in injury. Elderly people are far more prone to this kidney injury than younger people, as the elderly have less reserve.
Answered 2/28/2019
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