It could: All opiates cause release of histamine, and morphine, Codeine and Demerol have the most, and oxycodone, Methadone and fentanyl do it the least. However, they all can cause some histamine release, and some people get major problems with all of them. Levorphanol also can do this. You could take a Benadryl with it - talk to your doctor. Otherwise, use non-opioids-NSAIDs, tylenol, (acetaminophen) physical measures
Answered 6/14/2020
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