Yes, but why??: There are no bad interactions between zyrtec (cetirizine) and melatonin. They are safe to use together. The bigger question is why daily melatonin. I imagine it has to do with poor sleep initiation patterns, but without knowing more, i would talk to his pediatrician about its use. A usual safe dose for a 4 y/o is 3 or 5 mg at bedtime, but as important is bedtime routine, decreased stimulation, etc.
Answered 4/18/2019
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