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Silver Spring, MD
A 65-year-old male asked:

Why is sinemet (carbidopa and levodopa) cr is inferior to regular sinement in terms of strength even though they carry the same mg in terms of dose for parkinsons?

2 doctor answers4 doctors weighed in
Dr. Philip Miller
A Verified Doctoranswered
Family Medicine 47 years experience
Time release: Time released or controlled release Sinemet (carbidopa and levodopa) is not inferior- the drug is just released more slowly into the system.
Dr. Eric Weisman
Neurology 36 years experience
Different timing: CR is sustained release. Regular lasts only a few hours and tends to have more peaks and troughs. One can use both. Regular is given 3 to 4 times a day.

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