Is epiduo supposed to make my skin red and hot feeling?

Yes, especially the : Yes, especially the first 2wks of use. Try using it every other day for the first two weeks and then switch over to daily use. It will delay the acne fighting effect but it will decrease the irritation. Use sunscreen (SPF >50),hypoallergenic/non-comadogenic fragrance-free products & cleansers. Avoid other acne products if the burning increases and don't forget to follow up with your doctor.