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A 42-year-old member asked:

what defect is responsible for hodgkin lymphoma?

2 doctor answers4 doctors weighed in
Dr. Kelty Baker
Hematology 28 years experience
Risk of Hodgkin's dz: There is no one "defect" that causes hodgkin's disease, but risk factors include a high socioeconomic status, having a family member with the disease, prior epstein-barr virus infection (mononucleosis), and immunosuppression as a result of conditions like aids, organ or marrow transplantation, autoimmune disease, and immunosuppressant medications.
Dr. Matthew Fero
Medical Oncology 31 years experience
Hodgkin's lymphoma: is a malignancy of a type of B-lymphocytes, known as a Hodgkin and Reed-Sternberg cell (HRS). It has been a challenge to study this disease because the HRS cell secretes factors that causes it to be surrounded by large numbers of normal lymphocytes. LRS cell neoplasia appears to result from a combination of gene mutations, like other lymphomas; and are often infected with EBV (Epstein Barr virus).

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A 25-year-old member asked:

What causes an inhomogeneous spleen in hodgkin lymphoma?

2 doctor answers3 doctors weighed in
Dr. Stephen Noga
Medical Oncology 34 years experience
A radiology term: The normal spleen looks quite smooth on ct scans. If it is involved with disease such as with hodgkin or non-hodgkin lymphoma, it's appearance looks different on ct scan or pet/ct: no longer smooth and even but rather has different shades. This is an inhomogeneous appearance as opposed to a homogeneous one.
A 39-year-old member asked:

What can cause inhomogenous spleen in hodgkin lymphoma?

1 doctor answer2 doctors weighed in
Dr. Muhammad-ali Zaydan
Specializes in Hematology and Oncology
Lymphoma in spleen: Inhomogenious spleen refer to a ct scan reading where different area of the spleen might have different texture. In general some of these cases are nonspecific, some are related to ifarction (dead tissue) and some are related to lymphoma. In this case, if the patient is already diagnosed with hodgkins lymphoma, most probably these area are lyphoma in the spleen surrounded by normal spleen tissue.
A 37-year-old member asked:

How accurate is the testing for hodgkin lymphoma?

1 doctor answer2 doctors weighed in
Dr. Muhammad-ali Zaydan
Specializes in Hematology and Oncology
Pathology: The best testing for hodgkins lymphoma is pathology reading, which means taking a biopsy from the lymph node and bone marrow, slides prepared and read under microscope by an expert pathologist. It is rare for an expert pathologist to misdiagnose a hodgkins lymphoma. Definitely after diagnosis a complete radiologic work up is needed to establish the stage.
A 30-year-old member asked:

How can I tell if I have hodgkin lymphoma? Cant stop thinking about it.

1 doctor answer2 doctors weighed in
Dr. Andrew Turrisi
Radiation Oncology 47 years experience
Are you a medical: Student? Hd is not common, usually presents with a lump in a nodal bearing area, but liver, spleen or mediastinal/hilar chest nodes can cause bulk symptoms there. Fever, soaking night sweats, weight loss are called "b" symptoms. A doctor can do a physical exam and discern fro your story whether the imaging is needed and what blood tests (cbc, sed rate, serum copper, liver enzymes, bili)) to do.
A 36-year-old member asked:

What cure is for hodgkin lymphoma?

2 doctor answers5 doctors weighed in
Dr. Muhammad-ali Zaydan
Specializes in Hematology and Oncology
Chemotherapy: Hodgkins disease is one of the malignant diseases that are highly curable. Most patients respond well to standard chemotherapy, small percentage need a second type if chemotherapy and some may need bone marrow rransplantaion.

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Last updated May 5, 2015

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