A member asked:

Why did i develop a codeine allergy after taking it for 40 yrs?

A doctor has provided 1 answer

Dose related?: Many side effects of narcotic medications are not allergy, and are more likely at higher doses. They are a direct effect of the drug. Nausea, vomiting, itching and hives are all dose related direct effects of narcotic medications. If you have been taking narcotics for 20 years, you are more likely to need higher doses to achieve pain control and are at higher risk of the adverse effects also.

Answered 2/2/2017

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