I was taking prozac and wellbutrin (bupropion). started feeling very nonchalant about life and it scared me. stopped pro and started zoloft. same issue. ideas?

Same family: Prozac and Zoloft are the same family and deal with serontonin receptors. Wellbutrin hits the dopamine receptors and if they are blocked you can feel nonchalant. But the combination of Wellbutrin with any SSRI drug can do the same like celexa Paxil (paroxetine) etc. Check with your provider to see if you need two anti depressant and maybe they can change to a SNRI or another type of medication if two are ne

What is nonchalant?: I read both of your questions and it sounds like you suffer from depression which is helped with medication, when you say nonchalant about life , do you mean less worried and uptight? If that is the case, it is a good thing. But it sounds like you it worried you. What was the scary part of that feeling!

Please discuss this with your Psychiatrist and if you are lacking confidence in your Dr. please see another for a second opinion. Have a physical exam to rule out illness. Also you may want to add sessions with a Clinical Psychologist with expertise in multiple forms of psychotherapy on Zoom.