A member asked:

I have a a/g ratio of 3.0. 3 months ago it was 1.5. should i be concerned that it has gotten so high, so fast? what can cause it to be high?

7 doctors weighed in across 3 answers

See your doctor.: First, ask your doctor. A repeat test may help. If truly elevated, the A/G ratio may be the result of underproduction of immunoglobulins (Igs), or less likely, elevated albumin. More tests, such as liver function tests and serum protein electrophoresis, may be needed to determine the cause (which can range from benign to serious). These can be ordered by your doctor as appropriate. Best wishes!

Answered 12/2/2015

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Lots of causes: A/G is the Albumin:Globulin ratio. A high AG ratio could result from lower than normal immunoglobulins or a higher than normal amount of albumin. Why are you getting this checked? Do you have a chronic disease or infection that your doctor is monitoring? This link explains significance of A/G ratio http://labtestsonline.org/understanding/analytes/tp/tab/test/ Definitely ask your doctor.

Answered 8/14/2015

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Dr. David Masiello answered

Specializes in Hematology and Oncology

Probably Nothing: Labs that can fluctuate rapidly such as globulin levels should not cause immediate significant concern. The most appropriate course of action is to verify that this is correct by repeating the test. Recent illness, such as UTI can affect this value. If it persists, further testing of both serum albumin and immunoglobulin levels can be performed to asses the cause and likely pathology.

Answered 8/27/2015

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