120 days: Your body replaces red blood cells about every 120 days - of course, not all at once - but each cell is replaced. As it normally passes through lymph tissues (nodes, spleen), the "old" red blood cells are pulled out and a built-in self-destruct sequence called apoptosis is activated. The cell components are recycled for new cells. The heme is excreted in your stool which is what makes it brown.
Answered 8/10/2014
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