A member asked:

What is the connection between iga and ibd (crohns, uc)?

4 doctors weighed in across 2 answers

IgA: Immunoglobulin A is produced by intestinal epithelium. IgA is intended to be secreted into bowel lumen. It can back diffuse into blood and deposit in kidneys, inciting inflammation there. Crohn s disease increases this potential..

Answered 4/18/2017

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Dr. Carrie Cannon answered

Specializes in Family Medicine

Autoimmunity: There is IgA autoreactivity to epithelial cell lines. The body reacting to itself as foreign. Have a great day! http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906379/

Answered 8/9/2014

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