Could a reaction to otc nasal decongestant spray mimic a cluster headache?

Maybe: There is no solid scientific data to support the direct cause and effect notion of phenyephrine/oxymetazoline decongestant nasal sprays mimicing cluster headaches. Some link triggers to seasonal changes (fall/spring) or alcohol or extreme variations in body temperatures. The nasal decongestant association may have anecdotal support in certain individuals, but i haven't heard about it.