Would/can albuterol or duoneb be taken to help breathing even with a cold or flu and while using sterile saline solution for nasal spray?

Yes: The simple answer is yes. Stopping smoking will be very helpful as well.

Yes: Viral upper respiratory infections can often trigger the small airways in your lungs to constrict. Go ahead and try the albuterol. If it helps, you can continue. If it doesn't, you can move on to something different with advice from your doctor.

Yes..: If you are experiencing difficulty breathing with wheezing, shortness of breath, and cough along with that cold/flu, then yes, it might help you a lot. It should not interact with the use of a sterile saline nasal spray either. And just have to note that smoking is definitely not going to make you feel better faster with this kind of illness.

Yes, sometimes: Albuterol and/or Duonebs can help relax the bronchioles (tubes in the lungs that carry air) and improve cough and wheezing. However, if you have never used them before, you will need to ask your doctor if you can take it. If you already use it, continue to do so. If it helps, well and good. But if it does not help or you need to use it more often than prescribed, that is concerning:call your doc.