A member asked:

What is the difference between pernicious anemia and megaloblastic anemia?

A doctor has provided 1 answer
Dr. Liawaty Ho answered

Specializes in Hematology and Oncology

Big RBC: Pernicious anemia is deficiency of vitaminb12 due to autoimmune attack on cell of the stomach and antibody against intrinsic factor- presented with megaloblastic anemia. Pa is only one of the causes of megaloblastic anemia- however other causes that can cause def vitb12 , or folate (folic acid) or other drug eg. Bactrim- that inhibits dna synthesis in RBC production also can cause megaloblastic anemia.

Answered 11/15/2016

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