A member asked:

What is a megaloblastic anemia?

4 doctors weighed in across 2 answers
Dr. Liawaty Ho answered

Specializes in Hematology and Oncology

Big red blood cell : Is a type of anemia presented with big size of red blood cells- that results from inhibition of dna synthesis during red blood cell production.This leads to continuing cell growth without division. It is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid, deficiency in micronutrient- as well as others including drugs/chemo etc. Work up needs to be done.

Answered 4/27/2015

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Dr. Michael Engel answered

Specializes in Pediatric Hematology and Oncology

It literally means: Large rbcls. There are many causes, but a central tenet of megaloblastic anemias is a dys-synchrony between cytoplasmic and nuclear "maturation" during red cell development. The most common causes are nutritional, from either folate (folic acid) or B12 deficiency, or less commonly intrinsic factor deficiency (pernicious anemia). There are other less common causes. Work with your dr. To find the cause & fix it.

Answered 3/14/2016

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