A member asked:

I know it is not recommended to take more than one antihistamine pill per 24 hours, but some only last ~8 hours. which ones lasts for 24 hrs?

A doctor has provided 1 answer
Dr. Michael Palumbo answered

Specializes in Allergy and Immunology

From experience some of the newer antihistamines such as Xyzal (levocetirizine) and Clarinex seem to be effective for longer time periods. Most antihistamines however peak in effectiveness in the first few hours and start to wear off after 12-15 hours.

Answered Nov 2, 2019

3.9k views

Thank

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