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A 48-year-old member asked:

Igm is negative but igg is positive for lyme disease, what to do?

1 doctor answer2 doctors weighed in
Dr. Michael Rupp
Allergy and Immunology 23 years experience
Old Infection: This most likely means you had an old infection with lyme disease. Our bodies make IgM early in an infection and IgG later. Even once the infection is gone there will be detectable IgG for quite some time. This is part of how our body remembers previous infections so we can fight them off better if we get them again.
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Similar questions

A 31-year-old member asked:

Is it possible to have a Lyme infection with a negative IgG but positive igm?

1 doctor answer2 doctors weighed in
Dr. James Ferguson
Pediatrics 48 years experience
Yes: Igm is the immunoglobulin noted for coming out early in response to any illness, it fades over time while igg come out a bit later and stays up longer. If you have a positive IgM it indicates a early response, while igg would probably show up in a few months at which point the IgM would have declined.
Created for people with ongoing healthcare needs but benefits everyone.
IN
A 31-year-old male asked:

What is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

1 doctor answer2 doctors weighed in
Dr. Thomas Knecht
A Verified Doctoranswered
33 years experience
Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck!
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jun 21, 2018

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