A 19-year-old male asked:
Why don't people with hypopituitarism require mineralocorticoids?
1 doctor answer • 1 doctor weighed in
A Verified Doctoranswered
33 years experience
Different control: Hi. Good question. As you know, cortisol production by the adrenal cortex is exquisitely regulated by ACTH from the pituitary. In ACTH-deficiency (hypo pit.), cortisol must be replaced. The primary regulator of aldosterone production is the renin-angiotensin system, which does NOT involved the pituitary, and functions just fine in hypopituitarism. ACTH will acutely stimulate aldo, but is not req'd
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3.9k viewsAnswered >2 years ago
Last updated Jul 14, 2014
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