Why don't people with hypopituitarism require mineralocorticoids?

Different control: Hi. Good question. As you know, cortisol production by the adrenal cortex is exquisitely regulated by ACTH from the pituitary. In ACTH-deficiency (hypo pit.), cortisol must be replaced. The primary regulator of aldosterone production is the renin-angiotensin system, which does NOT involved the pituitary, and functions just fine in hypopituitarism. ACTH will acutely stimulate aldo, but is not req'd