HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

I want to know which of these two drugs is more effective for the treatment of severe depression: sertraline or amitriptyline...

A doctor has provided 1 answer
Dr. Heidi Fowler answered

Specializes in Psychiatry

That depends: they both have their purposes. Do side effect profile of amitriptyline - often see it used for purposes other than depression treatment.

Answered 5/24/2015

2.8k views

Thank

Related Questions

A member asked:

I was prescribed 10mg of Elavil for anxiety. Prozac (fluoxetine) gave me palpitations &Zoloft made me depressed. I'm so scared of side effects! Should I try this?

A doctor has provided 1 answer

A member asked:

Feeling really anxious and depressed more so than normally taking sertraline 3 weeks no change do I neef therapy? Diff meds?

A doctor has provided 1 answer

A member asked:

I want to know which of these two drugs is more likely to cause weight gain: sertraline or amitriptyline...

2 doctors weighed in across 2 answers

A member asked:

Next option for depression? I've taken almost all SSRIs, two SNRIs, Mirtazapine, Brintellex & Wellbutrin. Currently on 150mg sertraline, 50mg amitriptyline & concerta, but fatigue/anhedonia are constant. Not suicidal currently.

2 doctors weighed in across 2 answers

A member asked:

I was given 10mg Elavil (amitriptyline) for insomnia. Read up on drug, its an antidepressant. I don't have depression. Will this drug alter my mood or make me weird?

A doctor has provided 1 answer

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

I have really bad depression, pts, and I have bipolar. Im on endep 50mg twice a day Zoloft (sertraline) 100mg twice a day n zyprexa 10ml once daily, is it lifetime?
I was prescribed 10mg of Elavil for anxiety. Prozac gave me palpitations & Zoloft (sertraline) made me depressed. Should I try this? I'm so scared of side effects!
I want to know how many milligrams of amitriptyline equivalent to 75 of sertraline for the treatment of severe depression...
Hello, i have f32.2 , severe depression and panic attack. My treatment is 200 mg sertraline, acid valproic 600 mg , lorazepam when i need. Is ok this?
On 100 mg sertraline for anxiety/depression morning 30 mg amitriptaline night for nerve pain I am struggling with nerve pain which makes me so low ?

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.