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Smyrna, TN
A 25-year-old female asked:

I have very high levels of dhea (480) but borderline low cortisol (3.7). endocrinologist says pcos. i worry about adrenal fatigue. should i worry?

2 doctor answers3 doctors weighed in
Dr. Thomas Knecht
A Verified Doctoranswered
A US doctor answeredLearn more
Not normal: First of all there is no such thing as "adrenal fatigue" (not a real disease or condition). With high DHEA, you could have a steroidogenic enzyme deficiency causing congenital adrenal hyperplasia. Do you have any male-pattern hair growth? Irregular or absent periods? Other steroids & steroid intermediates I would check are: 17(OH)progesterone, Androstenedione, and testosterone; others to check too
Dr. Michael Fox
Fertility Medicine 34 years experience
No: DHEA is not the correct measure. I'm assuming it's the DHEAS (adrenal form). would suggest evaluating for LOCAH (late onset congenital adrenal hyperplasia). The evaluation should include the 3B OH enzyme in the ACTH stimulation test, therefore both the 17 OH Progesterone and the pregnenolone need to be measured. Also a repeat of the cortisol would maybe reveal a higher number. Hope this helps

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Last updated Jun 30, 2014

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