More than one factor: Often autoimmune disorders are thought to develop according to a "two hit" hypothesis. First there is a possible genetic predisposition for autoimmunity and then an environmental trigger to give rise to the clinical presentation of the disease. In non specific terms, a trigger could be infection, trauma, certain chemicals. RE: HIV +, some pts can develop autoimmunity but it is not common.
Answered 6/17/2014
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